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One clinical study used 1.5mm needles rolled until mild erythema appeared, followed by immediate peptide application

Chronic alcohol intake activates intrahepatic macrophages, releasing inflammatory cytokines such as TNF- and IL-1, which promote liver inflammation, lipid accumulation, and fibrosis (Zhou et al., 2022

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The DSS water was changed every 23 days, and the mice were weighed each day for at least 16 days